LINC00514 drives osteosarcoma progression through sponging microRNA-708 and consequently increases URGCP expression
نویسندگان
چکیده
منابع مشابه
MicroRNA signatures associate with pathogenesis and progression of osteosarcoma
Kevin B. Jones, Zaidoun Salah, Sara Del Mare, Marco Galasso, Eugenio Gaudio, Gerard J. Nuovo, Francesca Lovat, Kimberly LeBlanc, Jeff Palatini, R. Lor Randall, Stefano Volinia, Gary S. Stein, Carlo M. Croce, Jane B. Lian, Rami I. Aqeilan Department of Orthopaedics and Center for Children’s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; Lautenberg Center fo...
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BACKGROUND The cell-surface protein CD38 mediates airway smooth muscle (ASM) contractility by generating cyclic ADP-ribose, a calcium-mobilizing molecule. In human ASM cells, TNF-α augments CD38 expression transcriptionally by NF-κB and AP-1 activation and involving MAPK and PI3K signaling. CD38-/- mice develop attenuated airway hyperresponsiveness following allergen or cytokine challenge. The ...
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Osteosarcoma is the most common primary bone tumour. Increasing evidence has demonstrated the pathogenic role of microRNA (miRNAs) dysregulation in tumour development. miR-379 was previously reported to function as an oncogenic or tumour-suppressing miRNA in a tissue-dependent manner. However, its function in osteosarcoma remains unknown. In this study, we found that the expression of miR-379 w...
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BACKGROUND Osteosarcoma is the most common type of bone cancer and is notorious for its rapid progression. The Notch signaling pathway has recently been shown to be involved in osteosarcoma. As a major sheddase of Notch receptors, ADAM10 has been implicated in many types of cancers, but its role in osteosarcoma has not been investigated. Previous studies have shown that the expression of CD31 w...
متن کاملDown-regulation of microRNA-182 and microRNA-183 predicts progression of osteosarcoma
Introduction The aim of this study was to investigate the expression levels of microRNA-182 and microRNA-183 and their association with clinicopathological features in patients with osteosarcoma. Material and methods Total RNA was purified from samples and noncancerous bone tissues and then quantitative real-time polymerase chain reaction was applied to evaluate the expression levels of micro...
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ژورنال
عنوان ژورنال: Aging
سال: 2020
ISSN: 1945-4589
DOI: 10.18632/aging.103043